n-Butyl-β-D-fructofuranoside could be isolated from kangaisan. n-Butyl-β-D-fructofuranoside induces apoptosis through the mitochondrial pathway. n-Butyl-β-D-fructofuranoside can be used for cancer research[1].
n-Butyl-β-D-fructofuranoside (0-23.6 μg/mL; 24-78 hours) has antiproliferation activity and inhibits the viability of Bel-7402 cells[1].
n-Butyl-β-D-fructofuranoside (0-75 μg/mL; 0-72 hours) inhibits BEL-7402 cells by interfering with cell cycle and inducing apoptosis[1].
Cell Viability Assay[1]
| Cell Line: | Bel-7402 cells |
| Concentration: | 0.47, 2.95, 5.90, 11.8, 17.7 and 23.6 μg/mL |
| Incubation Time: | 24, 48 and 72 hours |
| Result: | Inhibited the proliferation of Bel-7402 cells at both time- and dose-dependent manner. |
Cell Cycle Analysis[1]
| Cell Line: | Bel-7402 cells |
| Concentration: | 0, 50 and 75 μg/mL |
| Incubation Time: | 24, 48 and 72 hours |
| Result: | Induced cell cycle arrest at G0/G1 phase. |
Western Blot Analysis[1]
| Cell Line: | Bel-7402 cells |
| Concentration: | 23.6 μg/mL |
| Incubation Time: | 0, 24, 48 and 72 hours |
| Result: | Decreased Bcl-2 and increased Bax and p53 levels in a time manner. |