N-(3-Oxooctanoyl)-DL-homoserine lactone is an N-acyl homoserine lactone (AHL) compound produced by Gram-negative bacteria that can regulate plant root growth activity[1, 2]. N-(3-Oxooctanoyl)-DL-homoserine lactone exhibits stereochemical structure dependence, with its S enantiomer promoting root germination more effectively than its R enantiomer, and both enantiomers inducing root cell elongation[1]. In quorum sensing systems, N-(3-Oxooctanoyl)-DL-homoserine lactone can bind to LuxR-type transcription factors (such as the TraR protein of Agrobacterium tumefaciens), forming a complex that interacts with DNA binding sites to regulate the expression of specific genes[3, 4].
References:
[1] Olher V G A, Ferreira N P, Souza A G, et al. Acyl-homoserine lactone from Saccharum× officinarum with stereochemistry-dependent growth regulatory activity[J]. Journal of natural products, 2016, 79(5): 1316-1321.
[2] Viswanath G, Sekar J, Ramalingam P V. Detection of diverse N-Acyl homoserine lactone signalling molecules among bacteria associated with rice rhizosphere[J]. Current microbiology, 2020, 77(11): 3480-3491.
[3] Kumar L, Patel S K S, Kharga K, et al. Molecular mechanisms and applications of N-acyl homoserine lactone-mediated quorum sensing in bacteria[J]. Molecules, 2022, 27(21): 7584.
[4] Styles M J. New models and methods for characterizing ligand-induced LuxR-type quorum sensing receptor activation and inhibition[M]. The University of Wisconsin-Madison, 2021.
N-(3-Oxooctanoyl)-DL-homoserine lactone是一种由革兰氏阴性菌产生的N-酰基高丝氨酸内酯（AHL）类化合物，能够调节植物根生长活性[1, 2]。N-(3-Oxooctanoyl)-DL-homoserine lactone具有立体化学结构依赖性，其S对映体比R对映体更有效地促进根萌发，两种对映体均能诱导根细胞伸长[1]。在群体感应系统中，N-(3-Oxooctanoyl)-DL-homoserine lactone能够与LuxR-type转录因子（如根癌农杆菌的TraR蛋白）结合，形成复合物后与DNA结合位点相互作用，从而调控特定基因的表达[3, 4]。