N-(2-Aminoethyl)maleimide is a thiol-reactive cross-linking agent.1,2 It has been used in the synthesis of maleimide-functionalized heparin hydrogels in the development of growth factor delivery systems and radiotracers for thiol-mediated protein labelling.
1.Nie, T., Baldwin, A.C., Yamaguchi, N., et al.Production of heparin-functionalized hydrogels for the development of responsive and controlled growth factor delivery systemsJ. Control Release122(3)287-296(2007) 2.Kratz, H., Haeckel, A., Michel, R.P., et al.Straightforward thiol-mediated protein labelling with DTPA: Synthesis of a highly active 111In-annexin A5-DTPA tracerEJNMMI Res.2(1)17(2012)