Myosmine-d4 is the deuterium labeled Myosmine. Myosmine, a specific tobacco alkaloid in nuts and nut products, has low affinity for a4b2 nicotinic acetylcholinergic receptors (nAChR) with a Ki of 3300 nM[1][2].
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References:
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2]. G Ferretti, er al. Binding of Nicotine and Homoazanicotine Analogues at Neuronal Nicotinic Acetylcholinergic (nACh) Receptors. Bioorg Med Chem Lett. 2003 Feb 24;13(4):733-5.
[3]. Wolfgang Zwickenpflug, et al. Metabolism of Myosmine in Wistar Rats. Drug Metab Dispos. 2005 Nov;33(11):1648-56.