Multi-Leu peptide (ML-peptide) triacetate is a potent inhibitor ofPACE4(Ki=22 nM). Multi-Leu peptide triacetate can competitively bind to the active site ofPACE4by simulating the substrate sequence ofPACE4, thereby inhibiting its catalytic activity. Multi-Leu peptide triacetate can be used to study the specific mechanism ofPACE4in the development of prostatecancer[1].
References:
[1].epek T, et al. Macrocyclization of a potent PACE4 inhibitor: Benefits and limitations[J]. European journal of cell biology, 2017, 96(5): 476-485.
Multi-Leu peptide (ML-peptide) triacetate 是一种PACE4的强效抑制剂 (Ki=22 nM)。Multi-Leu peptide triacetate 通过模拟PACE4的底物序列，与PACE4的活性位点竞争性结合，从而抑制其催化活性。Multi-Leu peptide triacetate 可以用于研究PACE4在前列腺癌发展中的具体作用机制。