GlpBio

MS47134

目录号: GC69503纯度: >99.00%
MS47134 是一种有效和选择性的 MRGPRX4 激动剂，EC50 为 149 nM。MS47134 可用于研究疼痛、瘙痒和肥大细胞介导的超敏反应。
MS47134
规格价格库存数量操作
10mg¥3,780.00现货
1
25mg¥7,560.00现货
1
50mg¥12,150.00现货
1
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文献被引

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    641, 529–536 (2025)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

MS47134 is a potent and selective MRGPRX4 agonist with an EC50 value of 149 nM. MS47134 can be used for research of pain, itch and mast cell-mediated persensitivity[1].

MS47134 exhibits increased potency as a MRGPRX4 agonist in the FLIPR Ca2+ assay compared with Nateglinide [1].
MS47134 (0.001 nM-0.1 mM) shows 47-fold improved selectivity for MRGPRX4 over the Kir6.2/SUR1 potassium channel[1].
The MRGPRX family of receptors (MRGPRX1-4) is a family of mas-related G-protein-coupled receptors that have evolved relatively recently. MRGPRX2 and MRGPRX4 are key psiological and pathological mediators of itch and related mast cell-mediated persensitivity reactions[1].

[1]. Cao C, et al. Structure, function and pharmacology of human itch GPCRs. Nature. 2021 Dec;600(7887):170-175.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

分子式
C22H29NO3
分子量
355.47 g/mol
溶解性
DMSO : 100 mg/mL (281.32 mM; Need ultrasonic)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol