MLS1082 is a pyrimidone-based D1-like dopamine receptor positive allosteric modulator, with an EC50 of 123 nM for DA-stimulated G protein signaling.
MLS1082 potentiate β-Arrestin- and G protein-Mediated D1R signaling[1].
References:
[1]. Kathryn D Luderman, et al. Development of pyrimidone D1 dopamine receptor positive allosteric modulators. Bioorg Med Chem Lett. 2021 Jan 1;31:127696.
[2]. Kathryn D Luderman, et al. Identification of Positive Allosteric Modulators of the D 1 Dopamine Receptor That Act at Diverse Binding Sites. Mol Pharmacol. 2018 Oct;94(4):1197-1209.