Milategrast is useful as cell adhesion inhibitor or cell infiltration inhibitor. Milategrast in vitro inhibites the adhesion of Jurkat cells to human fibronectin with an IC50 of <5 μM[1].
[1]. Kotake, Makoto; Yoneda, Naoki; Osada, Katsunobu.Preparation of various crystal forms and salts of 1-cyclopropylmetl-4-[2-(3,3,5,5-tetrametlcyclohexyl)phenyl]piperazine for treating or preventing various inflammatory diseases and autoimmune diseases.WO