MHI-148 is a near-infrared heptamethine cyanine dye with tumor-targeting properties (excitation/emission wavelengths: 740/950nm). MHI-148 can be specifically taken up and accumulated in the lysosomes and mitochondria of tumor cells via a hypoxia-mediated mechanism. MHI-148 can be used for research related to tumor detection, diagnosis, and photodynamic therapy[1-4].
References:
[1] Thomas RG, Moon MJ, Surendran SP, et al. MHI-148 Cyanine Dye Conjugated Chitosan Nanomicelle with NIR Light-Trigger Release Property as Cancer Targeting Theranostic Agent. Mol Imaging Biol. 2018 Aug;20(4):533-543.
[2] Choi PJ, Tomek P, Tercel M, et al. Conjugation of Palbociclib with MHI-148 Has an Increased Cytotoxic Effect for Breast Cancer Cells and an Altered Mechanism of Action. Molecules. 2022 Jan 27;27(3):880.
[3] Usama SM, Jiang Z, Pflug K, et al. Conjugation of Dasatinib with MHI-148 Has a Significant Advantageous Effect in Viability Assays for Glioblastoma Cells. ChemMedChem. 2019 Sep 4;14(17):1575-1579.
[4] Raveendran A, Poilil Surendran S, Ser J, et al. Heptamethine Cyanine Dye MHI-148-Mediated Drug Delivery System to Enhance the Anticancer Efficiency of Paclitaxel. Int J Nanomedicine. 2021 Oct 21;16:7169-7180.
MHI-148是一种近红外七甲氨酸菁染料，具有肿瘤靶向性（excitation/emission wavelengths: 740/950nm）。MHI-148可通过缺氧介导的机制被肿瘤细胞的溶酶体和线粒体特异性摄取并积累。MHI-148可用于肿瘤检测、诊断和光动力治疗的相关研究[1-4]。