Metrizamide is a non-ionic contrast agent.[1] In vivo, metrizamide (0.1 ml/kg of a 370 mg I/ml solution) does not induce EEG abnormalities, indicating minimal neurotoxicity in rabbits. It has also been used as a solute in gradient centrifugation applications.[2]
Reference:
[1]. Maly, P., Elmqvist, D., Almén, T., et al. Comparison between EEG and observation of rabbit behaviour in evaluation of subarachnoid neurotoxicity of metrizamide. Acta. Radiol. Diagn. (Stockh.) 27(2), 235*240 (1986).
[2]. Hsu, C.-H., Di Carlo, D., Chen, C., et al. Microvortex for focusing, guiding and sorting of particles. Lab Chip. 8(12), 2128-2134 (2008).