Mensacarcin is a bacterial metabolite that has been found in S. bottropensis and has anticancer activity.1,2 It is cytostatic in the NCI-60 panel of cancer cell lines (mean IC50 = 1.3 µM) and cytotoxic to HepG2, HM02, KATO III, and MCF-7 cells (IC50s = 0.4-50 µM).1 Mensacarcin induces apoptosis in SK-MEL-28 and SK-MEL-5 melanoma cells.2
1.Maier, S., PflÜger, T., Loesgen, S., et al.Insights into the bioactivity of mensacarcin and epoxide formation by MsnO8Chembiochem15(5)749-756(2014) 2.Plitzko, B., Kaweesa, E.N., and Loesgen, S.The natural product mensacarcin induces mitochondrial toxicity and apoptosis in melanoma cellsJ. Biol. Chem.292(51)21102-21116(2017)