Megazol is an orally active antibacterial agent. Megazol has effective inhibitory against T. b. brueei with an EC50 of 0.01 μg/mL. Megazol can be used for the research of protozoan infections.
Megazol has effective inhibitory against T. b. brueei AnTat 1-9 with an EC50 of 0.01 μg/mL[1].
Megazol (i.p. or p.o.; 20, 80 mg/kg) shows cure the acute disease in T. b. brueei infected Swiss mice[1].
Megazol alone not causes cure of mice carrying a subacute infection with involvement of the central nervous system (CNS) [1].
Megazol have remission effect combined suramin, without further relapse from the CNS[1].
References:
[1]. B Bouteille, et al. Effect of megazol on Trypanosoma brucei brucei acute and subacute infections in Swiss mice. Acta Trop. 1995 Oct;60(2):73-80.