GlpBio

MCI-INI-3

目录号: GC91980纯度: >95.00%
MCI-INI-3是醛脱氢酶1A3（ALDH1A3；Ki=0.55μM）的抑制剂。
MCI-INI-3
Cas No.: 1011366-31-6
规格价格库存数量操作
1 mg¥826.00现货
1
5 mg¥3,304.00现货
1
10 mg¥6,202.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    Science
    387(6734) (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

MCI-INI-3 is an inhibitor of aldehyde dehydrogenase 1A3 (ALDH1A3; Ki = 0.55 ?M).1 It is selective for ALDH1A3 over ALDH1A1 (Ki = 78.2 ?M). MCI-INI-3 (15 ?M) inhibits the conversion of retinol to retinaldehyde in U87MG glioblastoma cells. It reduces the viability of GSC-83 and GSC-326 glioblastoma cells when used at a concentration of 15 ?M.

References:
[1]. Li, J., Garavaglia, S., Ye, Z., et al.A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cellsCommun. Biol.4(1)1420(2021).

产品文档 Product Documents

Purity:>95.00%

化学性质Chemical Properties

CAS 号
1011366-31-6
化学名
5-(1,3-benzodioxol-5-yl)-2-phenyl-pyrazolo[1,5-a]pyrimidine-7-carboxylic acid, methyl ester
SMILES
O=C(C1=CC(C2=CC3=C(OCO3)C=C2)=NC4=CC(C5=CC=CC=C5)=NN41)OC
分子式
C21H15N3O4
分子量
373.4 g/mol
溶解性
Acetonitrile: Slightly soluble: 0.1-1 mg/ml,DMSO: Sparingly soluble: 1-10 mg/ml
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol