Luteolinidin chloride is an antioxidative deoxyanthocyanidin that can be isolated from the plant Sorghum bicolor[1-2]. Luteolinidin chloride is an effective CD38 inhibitor (Ki=11.4µM) and protects the heart from ischemia/reperfusion injury by preserving endothelial nitric oxide synthase function and preventing endothelial dysfunction [3-4].
In vitro, MC-65 neuronal cells were treated with Luteolinidin chloride (10–20µM) for 72 hours, followed by the induction of Aβ42 expression under tetracycline-free conditions to generate toxicity. Luteolinidin chloride protected MC-65 cells from Aβ42-induced damage, significantly increased cell survival rates, and enhanced mitochondrial function[5]. Isolated perfused rat hearts were pretreated with Luteolinidin chloride (5–50µM) for 20 minutes, followed by 30 minutes of global ischemia and 30-120 minutes of reperfusion. Luteolinidin chloride significantly improved left ventricular systolic function and coronary flow, while reducing myocardial infarction area[6].
References:
[1] Boslett J J. CD38 in the Heart: Effects of CD38 Activation on Post-Ischemic Injury[D]. The Ohio State University, 2017.
[2] Webb MR, Min K, Ebeler SE. Anthocyanin Interactions with DNA: Intercalation, Topoisomerase I Inhibition and Oxidative Reactions. J Food Biochem. 2008 Sep 23;32(5):576-596.
[3] Bianco-Gomes AC, Nogueira LDS, Bono-Lopes NVM, et al. Dry heat and pressure favor bioactive compounds preservation and peptides formation in sorghum [Sorghum bicolor (L.) Moench]. Curr Res Food Sci. 2022 Jan 4;5:117-124.
[4] Yang SY, Kim JH, Su X, et al. The Luteolinidin and Petunidin 3-O-Glucoside: A Competitive Inhibitor of Tyrosinase. Molecules. 2022 Sep 4;27(17):5703.
[5] Abdulraheem RA, Danazumi AU, Nitschke P, et al. 3-Deoxyanthocyanidins inhibit β-amyloid aggregation, toxicity, and mitochondrial dysfunction: Evidence from MC-65 cells and molecular dynamics simulations. Free Radic Biol Med. 2026 Feb 1;247:213-223.
[6] Boslett J, Hemann C, Zhao YJ, et al. Luteolinidin Protects the Postischemic Heart through CD38 Inhibition with Preservation of NAD(P)(H). J Pharmacol Exp Ther. 2017 Apr;361(1):99-108.
Luteolinidin chloride是一种具有抗氧化活性的脱氧花青素，可以从Sorghum bicolor植物中分离得到[1-2]。Luteolinidin chloride是一种有效的CD38（Ki=11.4μM）抑制剂，通过保护内皮型一氧化氮合酶功能和预防内皮功能障碍来保护心脏免受缺血/再灌注损伤[3-4]。
在体外，Luteolinidin chloride（10–20μM）处理MC-65神经细胞72小时，随后在无四环素条件下诱导Aβ42表达以产生毒性，Luteolinidin chloride保护MC-65细胞免受Aβ42造成的损伤，显著提高细胞存活率，同时增强线粒体功能[5]。Luteolinidin chloride （5–50μM）预处理离体灌注大鼠心脏20分钟，随后进行30分钟全局性缺血及30-120分钟再灌注，显著改善左心室收缩功能与冠脉流量，同时减少心肌梗死面积[6]。