LM11A-31 is a small molecule p75NTR Ligand that reverses cholinergic neurite dystrophy in alzheimer's diseasemousemodels with mid- to late-stage disease progression.
LM11A-31 greatly reduces or eliminates the neuronal pathology as well as the FIV effects on astrocytes and microglia in an infectious in vitro model, indicating an excellent potential for the treatment of HIV-associated neurodegeneration.[1]
LM11A-31 is a small molecular p75NTR ligand, which reverses cholinergic neurite dystrophy in mice with advanced Alzheimer's disease.[2]
[1] Meeker RB, et al. J Neuroimmune Pharmacol. 2012 Jun;7(2):388-400. "[2] Danielle A Simmons, et al. PLoS One . 2014 Aug 25;9(8):e102136.