GLPBio

Lipid PPz-2R1

目录号: GC92488纯度: >98.00%
Lipid PPz-2R1 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.
Lipid PPz-2R1
Cas No.: 2832061-40-0
规格价格库存数量操作
1mg¥1,063.00现货
1
5mg¥5,051.00现货
1
10mg¥9,563.00现货
1
25mg¥14,615.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

Lipid PPz-2R1 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing lipid PPz-2R1 and encapsulating an mRNA reporter selectively accumulate in lungs over the heart, liver, spleen, and kidneys in mice. LNPs containing lipid PPz-2R1 and encapsulating mRNA encoding phosphatase and tensin homolog (PTEN) increase PTEN protein levels in PTEN-deficient Lewis lung carcinoma (LLC) cells. Lipid PPz-2R1-containing LNPs encapsulating PTEN mRNA reduce tumor growth in an orthotopic murine LLC model when administered alone or in combination with an antibody targeting programmed cell death protein 1 (PD-1).

产品文档 Product Documents

Purity:>98.00%Appearance:A solution in ethanol

化学性质Chemical Properties

CAS 号
2832061-40-0
化学名
piperazine-1,4-diylbis(hexane-6,1-diyl) bis(2-hexyldecanoate)
SMILES
O=C(C(CCCCCC)CCCCCCCC)OCCCCCCN1CCN(CCCCCCOC(C(CCCCCCCC)CCCCCC)=O)CC1
分子式
C48H94N2O4
分子量
763.29 g/mol
溶解性
Ethanol: Soluble: ≥10 mg/ml
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol