Lipid HTO12 is an ionizable cationic lipid (pKa = 6.432) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.[1] LNPs containing lipid HTO12 and encapsulating adenine base editor mRNA targeting Pcsk9 reduce hepatic Pcsk9 levels in mice at a reduced ionizable lipid/total lipids-to-mRNA ratio than LNPs containing SM-102 .
References:
[1].Chen, Q., Wang, X., Zhang, Y., et al.Minimizing the ratio of ionizable lipid in lipid nanoparticles for in vivo base editingNatl. Sci. Rev.11(6)nwae135(2024).