Lipid C-1 is an ionizable cationic amino lipid and a derivative of SM-102 .[1] It has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro. LNPs containing lipid C-1 and encapsulating an mRNA reporter induce higher luciferase expression in Calu-3 cells than SM-102.
References:
[1].Lewis, M.M., Soto, M.R., Maier, E.Y., et al.Optimization of ionizable lipids for aerosolizable mRNA lipid nanoparticlesBioeng. Transl. Med.8(6)e10580(2023).
















