GLPBio

Lipid 12T-O14

目录号: GC92280纯度: >95.00%
Lipid 12T-O14 is an amidine-incorporated degradable (AID) lipid (pKa = 8.15) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA in vitro or in vivo.
Lipid 12T-O14
规格价格库存数量操作
1mg¥1,155.00现货
1
5mg¥5,482.00现货
1
10mg¥10,395.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

Lipid 12T-O14 is an amidine-incorporated degradable (AID) lipid (pKa = 8.15) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA in vitro or in vivo. LNPs containing lipid 12T-O14 and encapsulating GFP-targeting siRNA reduce GFP levels in HepG2-GFP cells. Intramuscular delivery of LNPs containing lipid 12T-O14 and encapsulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-encoding mRNA increases anti-SARS-CoV-2 spike protein IgG titers in mice in a prime and boost immunization regimen. LNPs containing lipid 12T-O14 accumulate in the liver, but LNPs containing both lipid 12T-O14 and MC3 can be tuned to target the lungs or the spleen.

产品文档 Product Documents

Purity:>95.00%

化学性质Chemical Properties

化学名
tetradecyl 3-((4-((4-decylphenyl)amino)-4-iminobutyl)thio)propanoate
SMILES
N=C(NC1=CC=C(C=C1)CCCCCCCCCC)CCCSCCC(OCCCCCCCCCCCCCC)=O
分子式
C37H66N2O2S
分子量
602.99822 g/mol
溶解性
Ethanol: Slightly soluble: 0.1-1 mg/ml; Methanol: Slightly soluble: 0.1-1 mg/ml
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol