Link N peptide is aproteoglycan aggregatesactivator in the extracellular matrix. Link N peptide can selectively activate the p38mitogen-activated protein kinase(MAPK) pathway to promote the expression of type I and II collagens in human intervertebral disc cells. Link N peptide is promising for research of intervertebral disc degeneration-related diseases[1][2].
References:
[1].Petit A, et al. Effect of synthetic link N peptide on the expression of type I and type II collagens in human intervertebral disc cells. Tissue Eng Part A. 2011 Apr;17(7-8):899-904.
Link N peptide 是一种细胞外基质中的蛋白聚糖聚集体 (proteoglycan aggregates) 激活剂。Link N peptide 能够选择性激活 p38 丝裂原活化蛋白激酶 (MAPK) 通路，促进人椎间盘细胞中 I 型和 II 型胶原蛋白的表达。Link N peptide 有望用于椎间盘退变相关疾病的研究。