Levobupivacaine-d9 (hydrochloride)

Levobupivacaine-d₉ is intended for use as an internal standard for the quantification of levobupivacaine by GC- or LC-MS. Levobupivacaine is a sodium channel blocker and local anesthetic, as well as the levorotary stereoisomer of bupivacaine .^1,2,3 It inhibits cardiac sodium channel currents (I_Na) by 57.8% in isolated guinea pig ventricular myocytes when used at a concentration of 10 μM.¹ Levobupivacaine (10 μM) reduces the maximal rate of depolarization (V_max) and action potential duration to 76.7 and 83.4% of controls, respectively, in isolated guinea pig papillary muscle.² It induces a complete block of proprioception, motor function, and nociception in the hindleg of rats when administered at a dose of 7.7 mM by percutaneous injection into the sciatic nerve.³