Landogrozumab (LY2495655) is an humanized anti-myostatin monoclonal antibody. Landogrozumab effectively improves muscle volume, hand grip strength and function. Landogrozumab can be used for the research of muscle wasting disease[1].
Landogrozumab (3 和 15 mg/kg；静脉注射 1 次) 影响杜氏肌营养不良老年小鼠的肌肉质量[1]。
| Animal Model: | Duchenne muscular dystrop (DMD) C57BL/10-mdx mouse model[1] |
| Dosage: | 3 and 50 mg/kg |
| Administration: | Intravenous injection; 3 and 50 mg/kg once |
| Result: | Increasesd muscle mass of aged mice at a dose of 50 mg/kg while 3 mg/kg showed no significant effects. |
[1]. Muramatsu H, et al. Novel myostatin-specific antibody enhances muscle strength in muscle disease models. Sci Rep. 2021 Jan 25;11(1):2160.