Lamin fragment has a peptide sequence of Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp.
The lamins are type V intermediate filaments which can be categorized as either A-type (lamin A, C) or B-type (lamin B1, B2) according to homology in sequence, biochemical properties and cellular localization during the cell cycle. Lamin polypeptides have an almost complete ǁ-helical conformation with multiple ǁ-helical domains separated by non-ǁ-helical linkers that are highly conserved in length and amino acid sequence.
Nuclear lamins are intermediate filament-type proteins that are the major building blocks of the nuclear lamina, a fibrous proteinaceous meshwork underlying the inner nuclear membrane. Lamins can also be localized in the nuclear interior, in a diffuse or spotted patter. Lamins also play roles in DNA replication, chromatin organization, spatial arrangement of nuclear pore complexes, nuclear growth, and anchorage of nuclear envelope proteins.
References:
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