L-Kynurenine-d4 is an aryl hydrocarbon receptor agonist [1]. L-Kynurenine-d4 is primarily used as an internal standard for the quantification of L-Kynurenine by GC or LC-MS [2]. L-Kynurenine is an intermediate product of the kynurenine pathway in tryptophan metabolism. L-Kynurenine is a metabolic marker for cancer, infection, and chronic inflammation [3-4].
References:
[1]. Russak EM, Bednarczyk EM. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb; 53(2): 211-216.
[2]. Fuertig R, Ceci A, Camus SM, et al. LC–MS/MS-based quantification of kynurenine metabolites, tryptophan, monoamines and neopterin in plasma, cerebrospinal fluid and brain. Bioanalysis. 2016 Sep 1;8(18):1903-1917.
[3]. Opitz CA, Litzenburger UM, Sahm F, et al. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature. 2011 Oct 13; 478(7368): 197-203.
[4]. Romani L, Fallarino F, De Luca A, et al. Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Nature. 2008 Jan 10;451(7175):211-215.
L-Kynurenine-d4是一种芳烃受体激动剂 [1]。L-Kynurenine-d4主要用作气相色谱或液相色谱-质谱定量L-Kynurenin的内标 [2]。L-Kynurenine是色氨酸代谢过程中Kynurenin途径的中间产物。L-Kynurenine是癌症、感染和慢性炎症的代谢标志物 [3-4]。