L-Arginine-d7 is intended for use as an internal standard for the quantification of L-arginine by GC- or LC-MS. L-Arginine is an amino acid and a precursor of nitric oxide (NO).1 L-Arginine is a substrate for NO synthase that is oxidized to form NO and L-citrulline. It enhances NO release induced by bradykinin or A23187 in porcine aortic endothelial cells.2 L-Arginine (30 and 300 mg/kg, i.v.) induces dilation of pial arterioles and increases cerebral blood flow in normotensive and spontaneously hypertensive rats.3 It also reduces infarct size by 35 and 28% in normotensive and spontaneously hypertensive rats, respectively, following middle cerebral artery occlusion.
1.Stuehr, D.J.Enzymes of the L-arginine to nitric oxide pathwayJ. Nutr.134(10 Suppl)2748S-2751S(2004) 2.Palmer, R.M.J., Ashton, D.S., and Moncada, S.Vascular endothelial cells synthesize nitric oxide from L-arginineNature333(6174)664-666(1988) 3.Morikawa, E., Moskowitz, M.A., Huang, Z., et al.L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the ratStroke25(2)429-435(1994)