KM04416, an isothiazolone derivative, is a potent glycerol-3-phosphate dedrogenase (GPD2) inhibitor. KM04416 significantly inhibits PNT1A cell proliferation[1][2].
KM04416 (20 µM; 48 小时) 对多种癌细胞系具有生长抑制作用[1]。
KM04416 (10 µM; 72小时) 显着抑制 PNT1A 细胞增殖[1]。
Cell Viability Assay[1]
| Cell Line: | Several cancer cell lines including MDA-MB-231 and AsPC-1 as well as Huh-7, HepG2, and SK-HEP-1 cells |
| Concentration: | 20 µM |
| Incubation Time: | 48 h |
| Result: | Had a growth inhibitory effect. |
Cell Proliferation Assay[2]
| Cell Line: | PNT1A cell |
| Concentration: | 10 µM |
| Incubation Time: | 72 h |
| Result: | Significantly inhibited PNT1A cell proliferation. |
[1]. Seun Oh, et al. Non-bioenergetic roles of mitochondrial GPD2 promote tumor progression. Theranostics. 2023 Jan 1;13(2):438-457.
[2]. Gurmit Singh, et al. Mitochondrial FAD-linked Glycerol-3-phosphate Dedrogenase: A Target for Cancer Therapeutics. Pharmaceuticals (Basel). 2014 Feb 11;7(2):192-206.