GLPBio

Klotho-derived Peptide 6 (acetate)

目录号: GC92261纯度: >95.00%同义词: Klotho (186-215) (human); KP6
Klotho-derived peptide 6 (KP6) is a synthetic peptide fragment that corresponds to amino acids 186-215 of the anti-aging protein Klotho.
Klotho-derived Peptide 6 (acetate)
规格价格库存数量操作
1mg¥2,649.00现货
1
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文献被引

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    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

Klotho-derived peptide 6 (KP6) is a synthetic peptide fragment that corresponds to amino acids 186-215 of the anti-aging protein Klotho. It inhibits Wnt1-induced increases in fibronectin and α-smooth muscle actin (α-SMA) levels in HKC-8 human proximal tubular cells. KP6 (5 µg/ml) also inhibits Wnt3a-induced activation of β-catenin in a reporter assay using HEK293T cells. In vivo, KP6 (1 mg/kg) increases survival and decreases urine albumin levels, renal pertrop, and glomerular injury in a mouse model of diabetic kidney disease induced by streptozotocin , advanced oxidation protein products, and unilateral nephrectomy.

产品文档 Product Documents

Purity:>95.00%

化学性质Chemical Properties

同义词
Klotho (186-215) (human); KP6
化学名
L-glutaminyl-L-prolyl-L-valyl-L-valyl-L-threonyl-L-leucyl-L-tyrosyl-L-histidyl-L-tryptophyl-L-α-aspartyl-L-leucyl-L-prolyl-L-glutaminyl-L-arginyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-alanyl-L-tyrosylglycylglycyl-L-tryptophyl-L-alanyl-L-asparaginyl-L-arginyl-L-alanyl-L-leucyl-L-alanyl-L-α-aspartyl-L-histidine, acetate
SMILES
O=C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@]([C@H](O[H])C)([H])C(N[C@H](C(N[C@@H](CC2=CC=C(O[H])C=C2)C(N[C@@H](CC3=CN([H])C=N3)C(N[C@@H](CC4=CN([H])C5=C4C=CC=C5)C(N[C@@H](CC(O)=O)C(N[C@H](C(N6CCC[C@H]6C(N[C@@H](CCC(N[H])=O)C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@H](C(N[C@@H](CCC(N[H])=O)C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](CC7=CC=C(O[H])C=C7)C(NCC(NCC(N[C@@H](CC8=CN([H])C9=C8C=CC=C9)C(N[C@H](C(N[C@@H](CC(N[H])=O)C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CC%10=CN([H])C=N%10)C(O)=O)=O)=O)C)=O)CC(C)C)=O)C)=O)=O)=O)C)=O)=O)=O)=O)=O)C)=O)=O)=O)CC(C)C)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)[C@H](CCC(N[H])=O)N[H].CC(O)=O
分子式
C159H232N46O44 • XC2H4O2
分子量
3491.82702 g/mol
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol