KLD-12 TFA

KLD-12 TFA is the TFA salt form of KLD-12 . KLD-12 TFA is a self a 12-residue self-assembling peptide that is used in tissue-engineering. KLD-12 TFA combined with SDF-1 self-assembled polypeptide enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs). KLD-12 TFA hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair.

KLD-12 TFA forms self-assembled polypeptide with SDF-1, improves the survival of bone marrow stromal cells (BMSCs), promotes osteogenic differentiation of BMSCs and cell migration through Wnt/β-catenin pathway^[1].

KLD-12 TFA (10-250 μg/rat, single dose, injection to infrature site) promotes bone regeneration at the fracture site in a dose-dependent manner in Sprague-Dawley rats model with drill-hole injury in femur^[2].

References:
[1]. Cao M, et al., Self-Assembled KLD-12/SDF-1 Polypeptide Promotes Differentiation and Migration of BMSCsviathe Wnt/β-catenin Signaling Pathways. Protein Pept Lett. 2022;29(10):851-858.
[2]. Tripathi JK, et al., Variants of self-assembling peptide, KLD-12 that show both rapid fracture healing and antimicrobial properties. Biomaterials. 2015 Jul;56:92-103.
[3]. Kisiday J, Jet al., Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9996-10001.