GlpBio

KISS1-305 (trifluoroacetate salt)

目录号: GC92094纯度: >98.00%同义词: D-Tyr-D-Pya(4)-Asn-Ser-Phe-azaGly-Leu-Arg(Me)-Phe-NH<sub>2</sub>
KISS1-305 (trifluoroacetate salt)是kisspeptin受体的肽激动剂。
KISS1-305 (trifluoroacetate salt)
规格价格库存数量操作
1 mg¥3,332.00现货
1
5 mg¥10,500.00现货
1
500 &#181;g¥1,750.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    641, 529–536 (2025)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

KISS1-305 is a peptide agonist of the kisspeptin receptor.1 It induces calcium mobilization in a reporter assay using CHO cells expressing the kisspeptin receptor (EC50 = 2.6 nM for the human receptor). KISS1-305 reduces plasma levels of testosterone below the limit of detection in male rats. It increases the number of ovulated oocytes in horse chorionic gonadotropin-stimulated immature female rats when administered at a dose of 100 nmol/kg.2

References:
[1]. Asami, T., Nishizawa, N., Matsui, H., et al.Physicochemically and pharmacokinetically stable nonapeptide KISS1 receptor agonists with highly potent testosterone-suppressive activityJ. Med. Chem.57(14)6105-6115(2014).
[2]. Asami, T., Nishizawa, N., Matsui, H., et al.Design, synthesis, and biological evaluation of novel investigational nonapeptide KISS1R agonists with testosterone-suppressive activityJ. Med. Chem.56(21)8298-8307(2013).

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

同义词
D-Tyr-D-Pya(4)-Asn-Ser-Phe-azaGly-Leu-Arg(Me)-Phe-NH<sub>2</sub>
化学名
D-tyrosyl-3-(4-pyridinyl)-D-alanyl-L-asparaginyl-L-seryl-L-phenylalanyl-2-azaglycyl-L-leucyl-N -[imino(methylamino)methyl]-L-ornithyl-L-phenylalaninamide, trifluoroacetate salt
SMILES
NC([C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(NC)=N)NC([C@H](CC(C)C)NC(NNC([C@H](CC2=CC=CC=C2)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](NC([C@H](N)CC3=CC=C(C=C3)O)=O)CC4=CC=NC=C4)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
分子式
C56H76N16O12 ? XCF3COOH
分子量
1165.3 g/mol
溶解性
Acetonitrile: Slightly soluble: 0.1-1 mg/ml,DMSO: Sparingly soluble: 1-10 mg/ml,Water: Slightly soluble: 0.1-1 mg/ml
保存条件
-20&#176;C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol