KIN1408 is a small molecule activator of the RIG-1-like receptor (RLR) pathway that has antiviral activity.1 It induces interferon regulatory factor 3 (IRF3) activation and translocation into the nucleus in a concentration-dependent manner in HEK293 cells without inducing cellular toxicity. KIN1408 induces expression of the innate immune genes MDA5, RIG-1, Mx1, IRF7, and IFIT1 in THP-1 cells stimulated with phorbol 12-myristate 12-acetate . It exhibits concentration-dependent broad-spectrum antiviral activity against dengue virus 2 as well as the influenza A, Ebola, Nipah, and Lassa viruses.
1.Pattabhi, S., Wilkins, C.R., Dong, R., et al.Targeting innate immunity for antiviral therapy through small molecule agonists of the RLR pathwayJ. Virol.90(5)2372-2387(2015)