KEMPFPKYPVEP Peptide is a peptide fragment of the dairy protein β-casein.[1],[2] It can be produced by the protease M from A. oryzae and is found in dairy products fermented by fungi but not bacteria.[1] KEMPFPKYPVEP Peptide (2 mg/kg) increases the levels of dopamine, norepinephrine, and homovanillic acid, but not serotonin, in the frontal cortex of mice. It improves spatial alternation retention in the Y-maze spatial alternation task and increases novel object exploration time in a novel object recognition test in a mouse model of scopolamine-induced amnesia when administered at a dose of 2 mg/kg.
References:
[1].Ano, Y., Kutsukake, T., Sasaki, T., et al.Identification of a novel peptide from β-casein that enhances spatial and object recognition memory in miceJ. Agric. Food Chem.67(29)8160-8167(2019).
[2].Atamer, Z., Post, A.E., Schubert, T., et al.Bovine β-casein: Isolation, properties and functionality. A reviewInt. Dairy J.66115-125(2017).