GlpBio

KBP-066 (trifluoroacetate salt)

目录号: GC92122纯度: >95.00%
KBP-066 (trifluoroacetate salt)是一种胰淀素和降钙素双重CT受体激动剂。
KBP-066 (trifluoroacetate salt)
规格价格库存数量操作
1 mg¥350.00现货
1
5 mg¥1,582.00现货
1
10 mg¥2,800.00现货
1
25 mg¥6,132.00现货
1
电话: 400-920-5774Email: sales@glpbio.cn

文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

KBP-066 is a dual amylin and calcitonin (CT) receptor agonist.1 It induces β-arrestin recruitment in cells expressing CT receptor subtype a or the amylin 3 receptor (AMY3) in a concentration-dependent manner. KBP-066 (50 ?g/kg) reduces body weight and food intake in rats fed a high-fat diet. It prevents increases in fasting blood glucose levels in fa/fa Zucker diabetic fatty rats.

References:
[1]. Sonne, N., Larsen, A.T., Andreassen, K.V., et al.The dual amylin and calcitonin receptor agonist, KBP-066, induces an equally potent weight loss across a broad dose range while higher doses may further improve insulin actionJ. Pharmacol. Exp. Ther.373(1)92-102(2020).

产品文档 Product Documents

Purity:>95.00%

化学性质Chemical Properties

SMILES
FC(F)(F)C(O)=O.NC([C@@H]1CCCN1C([C@H](C)NC([C@@H](NC([C@H](C)NC(CNC([C@@H](NC([C@H](CC(O)=O)NC([C@@]([H])(NC([C@@H](NC([C@@H]2CCCN2C([C@H](CC3=CC=C(C=C3)O)NC([C@@]([H])(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC4=CN=CN4)NC([C@@H](NC([C@H](CC(O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC(C(C)(NC([C@H](CS)NC([C@@]([H])(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CS)NC(C)=O)=O)CO)=O)CC(N)=O)=O)CC(C)C)=O)CO)=O)[C@H](O)C)=O)=O)C)=O)CC(C)C)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)CO)=O)CCC(N)=O)=O)=O)CC(C)C)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)CCC(N)=O)=O)[C@H](O)C)=O)=O)=O)CCCCN)=O)[C@H](O)C)=O)=O)C(C)C)=O)=O)=O)CC(N)=O)=O)=O)=O
分子式
C147H242N46O48S2 ? XCF3COOH
分子量
3485.9 g/mol
溶解性
DMSO: Soluble: ≥10 mg/ml,PBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol