K-Rasligand-Linker Conjugate 6 formate incorporates a ligand forK-Rasrecruiting moiety, and aPROTAClinker, which recruit E3ligases(such as VHL, CRBN,MDM2, andIAP).K-Rasligand-Linker Conjugate 6 formate can be used in the synthesis ofPROTACK-Ras Degrader-1 , which is potentPROTACK-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
References:
[1].CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.
K-Rasligand-Linker Conjugate 6 formate 包含靶蛋白K-Ras配体 (K-Ras募集基序) 和PROTAClinker，可募集 E3 连接酶 (如 VHL，CRBN，MDM2和IAP等类型)。K-Rasligand-Linker Conjugate 6 formate 可用于合成PROTACK-Ras Degrader-1 ，PROTACK-Ras Degrader-1 是一种有效的PROTACK-Ras 降解剂，在 SW1573 中对K-Ras的降解率 ≥70%。