JWH 250 N-(5-hydroxypentyl) metabolite-d5 contains five deuterium atoms at the 2, 4, 5, 6, and 7 positions. It is intended for use as an internal standard for the quantification of JWH 250 N-(5-hydroxypentyl) metabolite by GC- or LC-mass spectrometry. Cannabimimetic indoles, including certain "JWH" compounds, have been identified in herbal blends.1 Hydroxylated and glucuronidated metabolites of two closely-related compounds, JWH 015 and JWH 018, have been identified from in vitro liver microsomal metabolism and from urine, respectively.2,3,4 JWH 250 is a cannabimimetic indole that is structurally- and functionally-related to JWH 015 and JWH 018. JWH 250 N-(5-hydroxypentyl) metabolite is expected to be a metabolite of JWH 250 that would be detectable both in serum and in urine.
1.Uchiyama, N., Kikura-Hanajiri, R., Kawahara, N., et al.Identification of a cannabimimetic indole as a designer drug in a herbal productForensic Toxicol.2761-66(2009)
2.Zhang, Q., Ma, P., Cole, R.B., et al.Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MSAnalytical and Bioanalytical Chemistry3861345-1355(2006)
3.Sobolevsky, T., Prasolov, I., and Rodchenkov, G.Detection of JWH-018 metabolites in smoking mixture post-administration urineForensic Sci. Int.200(1-3)141-147(2010)
4.Moran, C.L., Le, V.H., Chimalakonda, K.C., et al.Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urineAnal. Chem.83(11)4228-4236(2011)
