JWH 073 N-(1,1-dimethylethyl) isomer

JWH 073 is a synthetic cannabinoid (CB) that activates both the central cannabinoid (CB₁) and peripheral cannabinoid (CB₂) receptors (K_i = 8.9 and 38 nM, respectively).¹ This cannabimimetic compound has been found in herbal blends.^2,3,4 JWH 073 N-(1,1-dimethylethyl) isomer differs structurally from JWH 073 by having a 1,1-dimethylethyl group, rather than a butyl chain, extending from the indole group. The biological activities of this compound have not been characterized. This product is intended for forensic and research applications.

1.Aung, M.M., Griffin, G., Huffman, J.W., et al.Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor bindingDrug Alcohol Depend.60(2)133-140(2000) 2.Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y.Survey of current trends in the abuse of psychotropic substances and plants in JapanLeg. Med. (Tokyo)13(3)109-115(2011) 3.Lindigkeit, R., Boehme, A., Eiserloh, I., et al.Spice: A never ending story•Forensic Science International19158-63(2009) 4.Uchiyama, N., Kikura-Hanajiri, R., Ogata, J., et al.Chemical analysis of synthetic cannabinoids as designer drugs in herbal productsForensic Science International19831-38(2010)