JWH 019 N-(5-hydroxyhexyl) metabolite-d5 contains five deuterium atoms at the 2, 4, 5, 6, and 7 positions. It is intended for use as an internal standard for the quantification of acetyl norfentanyl by GC- or LC-mass spectrometry. JWH 019 N-(5-hydroxyhexyl) metabolite-d5 contains five deuterium atoms at the 2, 4, 5, 6, and 7 positions. It is intended for use as an internal standard for the quantification of acetyl norfentanyl by GC- or LC-mass spectrometry. Cannabimimetic indoles, including certain JWH compounds, have been identified in herbal blends. JWH 018, a potent agonist of both the central cannabinoid (CB1) receptor and peripheral cannabinoid (CB2) receptor, has been found in many herbal blends and has been regulated in the United States and other countries. Studies indicate that JWH 018 is rapidly metabolized by the liver and that certain metabolites can be identified in the urine.1,2,3 JWH 019 is nearly identical to JWH 018 in structure and activity at both CB receptors.4 JWH 019 N-(5-hydroxyhexyl) metabolite is an expected metabolite of JWH 019, detectable both in serum and urine. Its biological activities have not been evaluated.
1.Teske, J., Weller, J.P., Fieguth, A., et al.Sensitive and rapid quantification of the cannabinoid receptor agonist naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) in human serum by liquid chromatography-tandem mass spectrometryJournal of Chromatography B8782659-2663(2010)
2.Sobolevsky, T., Prasolov, I., and Rodchenkov, G.Detection of JWH-018 metabolites in smoking mixture post-administration urineForensic Sci. Int.200(1-3)141-147(2010)
3.Wintermeyer, A., MÖller, I., Thevis, M., et al.In vitro phase I metabolism of the synthetic cannabimimetic JWH-018Anal. Bioanal. Chem.398(5)2141-2153(2010)
4.Aung, M.M., Griffin, G., Huffman, J.W., et al.Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor bindingDrug Alcohol Depend.60(2)133-140(2000)
