GlpBio

JH-LPH-28

目录号: GC69313纯度: >98%
COASDSData Sheet
JH-LPH-28 是磺酰基哌嗪类似物，是一种有效的 UDP-2,3-二酰基葡糖胺焦磷酸水解酶 LpxH 抑制剂。JH-LPH-28 具有出色的抗生素活性，MIC 值为 0.83 μg/mL。
JH-LPH-28
Cas No.: 2414592-36-0
规格价格库存数量操作
5mg¥648.00现货
1
10mg¥1,035.00现货
1
25mg¥2,070.00现货
1
50mg¥3,321.00现货
1
100mg¥5,310.00现货
1
10mM (in 1mL DMSO)¥672.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    641, 529–536 (2025)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    387(6734) (2025)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

JH-LPH-28, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate drolase LpxH inhibitor. JH-LPH-28 displays outstanding antibiotic activity with a MIC value of 0.83 μg/mL[1].

JH-LPH-28 displays IC50 values of 0.11 μM against K. pneumoniae LpxH and 0.083 μM against E. coli LpxH, respectively[1].
JH-LPH-28 potently inhibits bacterial growth at 2.8 μg/mL and displayes a MIC value of 1.6 μg/mL against wild-type K. pneumoniae (ATCC 10031)[1].

[1]. Cho J, et al. Structural basis of the UDP-diacylglucosamine pyrophosphodrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4109-4116.

产品文档 Product Documents

Purity:>98%
COASDSData Sheet

化学性质Chemical Properties

CAS 号
2414592-36-0
分子式
C21H21F4N3O3S
分子量
471.47 g/mol
溶解性
DMSO : 12.5 mg/mL (26.51 mM; ultrasonic and warming and heat to 60°C)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol