GlpBio

JBSNF-000028 TFA

目录号: GC69310纯度: >99.00%
JBSNF-000028 TFA 是一种具有口服活性的烟酰胺 N-甲基转移酶 (NNMT) 抑制剂，对人 NNMT (hNNMT)、猴 NNMT (mkNNMT) 和小鼠 NNMT (mNNMT) 的 IC50 分别为 0.033 μM、0.19 μM 和 0.21 μM。
JBSNF-000028 TFA
规格价格库存数量操作
10mg¥5,130.00现货
1
25mg¥10,350.00现货
1
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文献被引

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    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6734) (2025)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

JBSNF-000028 TFA is an orally active nicotinamide N-metltransferase (NNMT) inhibitor with IC50s of 0.033 μM, 0.19 μM and 0.21 μM against human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT), respectively. JBSNF-000028 TFA can be used for the research of metabolic disorders[1].

JBSNF-000028 TFA (24 h) inhibits NNMT activity with an EC50 of 2.5 μM in U2OS cells[1].
JBSNF-000028 TFA (10-100 μM; 72 h) has no cytotoxicity against HepG2 cells[1].
JBSNF-000028 TFA binds below a hairpin structural motif at the nicotinamide pocket and stacks between Tyr-204 (from Hairpin) and Leu-164 (from central domain)[1].
JBSNF-000028 TFA is inactive against a broad panel of targets related to metabolism and safety[1].

JBSNF-000028 TFA (50 mg/kg; p.o.; twice daily for 27 days) improves glucose and lipid handling in mice with diet-induced obesity (DIO)[1].
JBSNF-000028 TFA (50 mg/kg; p.o.; twice daily for 4 weeks) improves glucose tolerance in NNMT knockout mice with diet-induced obesity[1].

[1]. Ruf S, et al. Novel tricyclic small molecule inhibitors of Nicotinamide N-metltransferase for the treatment of metabolic disorders. Sci Rep. 2022 Sep 14;12(1):15440.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

分子式
C13H14F3N3O2
分子量
301.26 g/mol
溶解性
DMSO : ≥ 100 mg/mL (331.94 mM)
保存条件
4°C, away from moisture and light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol