IZ-Chol is an ionizable cationic lipid (pKas = 7.29 and 3.96) containing cholesterol .[1] LNPs containing IZ-chol can be complexed with DNA, with the plasmid-binding efficacy dependent, in part, on the type of helper lipids in the LNP formulation.
References:
[1].Wang, Y., Jiang, J., Ding, Z., et al.Design, synthesis, and in vitro gene transfer efficacy of novel ionizable cholesterol derivativesJ. Liposome Res.(2024).