Iturin A-2

Iturin A-2 is a cyclic lipopeptide that has been found in B. subtilis and has diverse biological activities.^1,2,3,4 It is active against the plant pathogenic fungus P. expansum (MIC = 8 µg/disk).¹ Iturin A-2 induces cytotoxicity in MCF-7 and BT474 breast cancer and HeLa cervical cancer cells (IC₅₀s = 66.81, 95.04, and 77.5 µg/ml, respectively).² It reduces southern corn leaf blight lesion area induced by B. maydis in greenhouse studies when applied at concentrations of 100 and 300 mg/kg AI and reduces the incidence of southern corn leaf blight in field studies at 300 and 500 mg/kg AI.³ Iturin A-2 (12.5 µg/ml) inhibits cell division, but not nuclear division, in isolated fertilized starfish eggs.⁴