ISX-1 is an isoxazole. ISX-1 has anti-adipogenic and pro-osteogenic activities. ISX-1 can be used for the research of osteopenia and osteoporosis.
ISX-1 dose-dependently inhibits the accumulation of intracellular lipid droplets and stimulated ALP activity[1].
ISX-1 can form lipid droplet with an IC50 value of 1.9 μM and also can induce ALP with an EC50 value of 1.2 μM[1].
ISX-1 (0, 1.3, 6.5 and 33 μM; 3 days) inhibited the mRNA induction of PPARγ and FABP4 genes under the adipogenic differentiation of hBMSCs[1].
ISX-1 (0, 1.3, 6.5 and 33 μM) promotes TCF/LEF-mediated gene transcription[1].
References:
[1]. Nawa, Katsuhiko et al. Discovering small molecules that inhibit adipogenesis and promote osteoblastogenesis: unique screening and Oncostatin M-like activity. Differentiation. 2013 Jul-Sep;86(1-2):65-74.