| 规格 | 价格 | 库存 | 数量 | 操作 |
|---|---|---|---|---|
| 1mg | ¥900.00 | 现货 | 1 | |
| 5mg | ¥1,800.00 | 现货 | 1 | |
| 10mg | ¥2,880.00 | 现货 | 1 | |
| 25mg | ¥5,184.00 | 现货 | 1 | |
| 10mM (in 1mL DMSO) | ¥1,814.00 | 现货 | 1 |
Ingliforib (CP 368296) is a glycogen phosphorylase (GP) inhibitor, with IC50s of 52, 352 and 150 nM for liver, muscle and brain glycogen phosphorylase, and has cardioprotective activity.
[1] Tracey WR, et al. Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H1177-84.
|
Animal experiment: |
Rabbits[1]Male New Zealand White rabbits (3 to 4 kg) are used in the assay. At least 1 h after surgery, when arterial pressure, heart rate (HR), and rate-pressure product (RPP) have stabilized for at least 30 min (baseline), the rabbits receive a bolus of either 15.4 mg/kg of Ingliforib or vehicle (administered in 15 s), followed by a constant infusion of 23.1 mg/kg/h Ingliforib or vehicle at the same dose volume for a total of 3.5 h. |
|
References: [1]. Tracey WR, et al. Cardioprotective effects of ingliforib, a novel glycogen phosphorylase inhibitor. Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H1177-84. |
