GlpBio

ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine)

目录号: GC32179纯度: >99.50%同义词: N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine
ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) 是具有抗寄生虫活性的 SK 通道抑制剂，IC50 为 2.1 μM.
ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine)
Cas No.: 3374-88-7
规格价格库存数量操作
1mg¥1,350.00现货
1
5mg¥3,240.00现货
1
10mg¥4,860.00现货
1
10mM (in 1mL DMSO)¥3,776.00现货
1
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文献被引

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    Cell
    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 µM.

The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters[2].

[1]. Bhuniya D, et al. Aminothiazoles: Hit to lead development to identify antileishmanial agents. Eur J Med Chem. 2015 Sep 18;102:582-93. [2]. Skibsbye L, et al. Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium. J Cardiovasc Pharmacol. 2015 Aug;66(2):165-76.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
3374-88-7
同义词
N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine
SMILES
C1(NC2=NC(C3=NC=CC=C3)=CS2)=NC=CC=C1
分子式
C13H10N4S
分子量
254.31 g/mol
溶解性
DMSO : ≥ 49.5 mg/mL (194.64 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol