3’-Hydroxygenkwanin is a flavonoid that has been found in B. balsamifera and has antioxidant and anticancer activities.1,2 It scavenges superoxide anions in a cell-free assay when used at a concentration of 100 ?M.1 3’-Hydroxygenkwanin (25 and 50 ?M) decreases the levels of EGFR and phosphorylated EGFR in, and reduces viability of, PC-9 and H1975 non-small cell lung cancer (NSCLC) cells.2 It also decreases intratumoral levels of EGFR and phosphorylated EGFR and reduces tumor growth in an H1975 mouse xenograft model when administered at a dose of 1 mg/kg.
1.Fazilatun, N., Nornisah, M., and Zhari, I.Superoxide radical scavenging properties of extracts and flavonoids isolated from the leaves of Blumea balsamiferaPharm. Biol.42(6)404–408(2004) 2.Leu, Y.-L., Wang, T.-H., Wu, C.-C., et al.Hydroxygenkwanin suppresses non-small cell lung cancer progression by enhancing EGFR degradationMolecules25(4)941(2020)