HS-PEG3-CH2CH2NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. HS-HS-PEG3-CH2CH2NH2 can be used to prepare gold nanoparticles in deionized water to develop luminescent "nanochips" (LAON), which helps to prevent or reduce biological interference[2]. HS-PEG3-CH2CH2NH2 can be used as an internal reference to optimize the mass spectrometry detection protocol for characterizing different HS-PEG linkers[3].
References:
[1] An S, Fu L. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs[J]. EBioMedicine, 2018, 36: 553-562.
[2] Gao Y, Huang Y, Chen J, et al. A novel luminescent “nanochip” as a tandem catalytic system for chemiluminescent detection of sweat glucose[J]. Analytical chemistry, 2021, 93(30): 10593-10600.
[3] Sato H, Kataoka Y, Nishikawa Y, et al. Efficient two-step chemoenzymatic conjugation of antibody fragments with reporter compounds by a specific thiol-PEG-amine Linker, HS-PEG-NH2[J]. PloS one, 2025, 20(10): e0333359.
HS-PEG3-CH2CH2NH2是一种基于聚乙二醇（PEG）的PROTAC连接子，可用于PROTAC的合成[1]。HS-PEG3-CH2CH2NH2可在去离子水中制备金纳米颗粒以开发发光“纳米芯片”（LAON），有助于防止或减少生物干扰[2]。HS-PEG3-CH2CH2NH2可用作内参，以优化用于表征不同HS-PEG连接子的质谱检测方案[3]。