GlpBio

Homo-PROTAC pVHL30 degrader 1

目录号: GC65285纯度: >99.00%
Homo-PROTAC pVHL30 degrader 1 是基于 PROTAC 的有效 pVHL30 降解剂。
Homo-PROTAC pVHL30 degrader 1
Cas No.: 2244684-49-7
规格价格库存数量操作
5mg¥1,440.00现货
1
10mg¥1,800.00现货
1
25mg¥3,600.00现货
1
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文献被引

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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC[1], consists of two ligands of von Hippel-Lindau.

Homo-PROTAC pVHL30 degrader 1 dimerizes von Hippel-Lindau (VHL) with high avidity in vitro and induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response[1].

[1]. Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
2244684-49-7
分子式
C58H82N8O14S2
分子量
1179.45 g/mol
溶解性
DMSO : ≥ 150 mg/mL (127.18 mM)
保存条件
4°C, stored under nitrogen
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol