Hesperetin 7-O-glucoside is a flavanone glucoside that has been found in immature citrus fruits and has diverse biological activities.1,2,3 It active against H. pylori when used at a concentration of 0.5 mM.2 Hesperetin 7-O-glucoside scavenges DPPH radicals (IC50 = 2.04 mM) and inhibits the activity of intestinal maltase and HMG-CoA reductase (Kis = 1,800 and 9.8 ?M, respectively, for the human enzymes) in cell-free assays.1,2 Dietary administration of hesperetin 7-O-glucoside (2.5 and 5 g/kg diet) prevents decreases in bone mineral density in the femur of ovariectomized rats.3
1.Liu, A., Huang, B., Lei, L., et al.Production of high antioxidant activity flavonoid monoglucosides from citrus flavanone with immobilised α-L-rhamnosidase in one stepInt. J. Food Sci. Tech.54(10)2854-2862(2019) 2.Lee, Y.-S., Huh, J.-Y., Nam, S.-H., et al.Enzymatic bioconversion of citrus hesperidin by Aspergillus sojae naringinase: Enhanced solubility of hesperetin-7-O-glucoside with in vitro inhibition of human intestinal maltase, HMG-CoA reductase, and growth of Helicobacter pyloriFood Chem.135(4)2253-2259(2012) 3.Habauzit, V., Nielsen, I.-L., Gil-Izquierdo, A., et al.Increased bioavailability of hesperetin-7-glucoside compared with hesperidin results in more efficient prevention of bone loss in adult ovariectomised ratsBr. J. Nutr.102(7)976-984(2009)