GlpBio

Herniarin (7-Methoxycoumarin)

目录号: GC34148纯度: >99.50%同义词: 7-甲氧基香豆素; 7-Methoxycoumarin; Methyl umbelliferyl ether
A coumarin with diverse biological activities
Herniarin (7-Methoxycoumarin)
Cas No.: 531-59-9
规格价格库存数量操作
100mg¥218.00现货
1
10mM (in 1mL DMSO)¥240.00现货
1
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产品描述 Description

7-Methoxycoumarin is a coumarin that has been found in S. oblongifolia and has diverse biological activities.1,2,3 It reduces the release of prostaglandin E2 and leukotriene C4 induced by A23187 in isolated mouse peritoneal macrophages.1 7-Methyoxycoumarin is active against S. aureus, S. epidermidis, B. subtilis, S. lutea, and V. cholera (MICs = 0.5, 0.75, 0.75, 0.75, and 0.5 mg/ml, respectively).2 In vivo, 7-methoxycoumarin (3.5 and 7 mg/kg) reduces formalin-induced paw licking and biting responses in mice.3

1.Silván, A.M., Abad, M.J., Bermejo, P., et al.Antiinflammatory activity of coumarins from Santolina oblongifoliaJ. Nat. Prod.59(12)1183-1185(1996) 2.Canales-Martínez, M., Hernández-Delgado, T., Flores-Ortiz, C., et al.Antimicrobial activity of Alternanthera caracasanaPharm. Biol.43(4)305-307(2005) 3.Cheriyan, B.V., Sr., Kadhirvelu, P., Sr., Nadipelly, J., Jr., et al.Anti-nociceptive effect of 7-methoxy coumarin from Eupatorium triplinerve vahl (Asteraceae)Pharmacogn. Mag.13(49)81-84(2017)

实验参考方法 Experimental Reference Method

Cell experiment:

Briefly, the cells are seeded (104 cells per well) onto flat-bottomed 96-well culture plates and allowed to grow 72 h after treatment with various concentration of auraptene, Herniarin, umbelliferone, and umbelliprenin. After removing the medium, MTT solution (5 mg/mL in PBS) is added and incubated for 4 h and the resulting formazan is solubilized with DMSO (100 mL). The absorption is measured at 570 nm (620 nm as a reference) in an ELISA reader[1].

References:

[1]. Mousavi SH, et al. Comparative analysis of the cytotoxic effect of 7-prenyloxycoumarin compounds and herniarin on MCF-7 cell line. Avicenna J Phytomed. 2015 Nov-Dec;5(6):520-30.
[2]. Haghighitalab A, et al. Enhancement of cisplatin cytotoxicity in combination with herniarin in vitro. Drug Chem Toxicol. 2014 Apr;37(2):156-62.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
531-59-9
同义词
7-甲氧基香豆素; 7-Methoxycoumarin; Methyl umbelliferyl ether
SMILES
O=C1C=CC2=CC=C(OC)C=C2O1
分子式
C10H8O3
分子量
176.17 g/mol
溶解性
DMSO : ≥ 125 mg/mL (709.54 mM)
保存条件
4°C, protect from light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol