Heparin-binding peptide is a synthetic peptide fragment corresponding to residues 1,892-1,899 of the C-terminal heparin-binding domain of fibronectin.[1] It induces focal adhesion formation in pre-spread human embryonic fibroblasts (HEFs) when used at concentrations ranging from 1 to 1,000 µg/ml. Heparin-binding peptide inhibits the production of matrix metalloproteinase 1 (MMP-1), MMP-2, and MMP-9 induced by a 40 kDa C-terminal heparin-binding fibronectin fragment (HBFN-f) in isolated human articular cartilage.[2] It has been used in peptide surface micropatterning for surface endothelialization.[3]
References:
[1].Woods, A., McCarthy, J.B., Furcht, L.T., et al.A synthetic peptide from the COOH-terminal heparin-binding domain of fibronectin promotes focal adhesion formationMol. Biol. Cell4(6)605-613(1993).
[2].Yasuda, T., Poole, A.R., Shimizu, M., et al.Involvement of CD44 in induction of matrix metalloproteinases by a COOH-terminal heparin-binding fragment of fibronectin in human articular cartilage in cultureArthritis Rheum.48(5)1271-1280(2003).
[3].Hoesli, C.A., Tremblay, C., Juneau, P.-M., et al.Dynamics of endothelial cell responses to laminar shear stress on surfaces functionalized with fibronectin-derived peptidesACS Biomater Sci. Eng.4(11)3779-3791(2018).