Helioxanthin (ACH126447) is a novel inhibitor of HBV, HCV and HSV-1 virus with EC50 values of 1 μM, 3 μM and 2 μM, respectively [1].
Helioxanthin has shown significant antiviral effect on HBV, HCV and HSV-1 virus in vitro with EC50 values of 1 μM, 3 μM and 2 μM, respectively. In a cell culture model, the level of HBV RNA, the expression of HBV antigen and its replication were all reduced by helioxanthin. Besides, helioxanthin has been exhibited to have a low cytotoxicity on both MT-223 and CEM24 cell lines with ID50 values of 2.5 μM and 31 μM, respectively [1].
Reference:
[1] Yeo H1, Li Y, Fu L, Zhu JL, Gullen EA, Dutschman GE, Lee Y, Chung R, Huang ES, Austin DJ, Cheng YC. Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48(2):534-46.